Pathologic Changes of Cone Photoreceptors in Eyes With Occult Macular Dystrophy

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Pathologic Changes of Cone Photoreceptors in Eyes With Occult Macular Dystrophy.

PURPOSE Occult macular dystrophy (OMD) is an inherited retinal disease characterized by a progressive decrease of vision and appearance of normal fundus. To determine the pathologic features of OMD, we investigated the alternation of the photoreceptors using quantitative image analysis. METHODS We studied 22 eyes of 11 OMD patients. Three of them had a mutation (R45W) in RP1L1. The relative i...

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Analysis of macular cone photoreceptors in a case of occult macular dystrophy

PURPOSE To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OCT) in a case of occult macular dystrophy (OMD). PATIENT AND METHODS Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five ...

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Occult Macular Dystrophy

Occult macular dystrophy is an inherited macular dystrophy characterized by a progressive decline of bilateral visual acuity with normal fundus appearance, fluorescein angiogram and full-field electroretinogram. This case report presents a 20-year-old female patient with bilateral progressive decline of visual acuity for six years. Her visual acuity was 3-4/10 in both eyes. Anterior segment and...

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Focal Functional and Microstructural Changes of Photoreceptors in Eyes with Acute Zonal Occult Outer Retinopathy

PURPOSE Acute zonal occult outer retinopathy (AZOOR) is characterized by an acute zonal loss of outer retinal function with minimal ophthalmoscopic changes in one or both eyes. We present a patient with AZOOR whose ultrastructural and functional findings were followed for 8 months. CASE A 22-year-old woman developed an acute central scotoma in her right eye. Her best-corrected visual acuity (...

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Multifocal electroretinogram in occult macular dystrophy.

PURPOSE Occult macular dystrophy (OMD) is an unusual macular dystrophy presenting with an essentially normal fundus and fluorescein angiography but with progressive central visual loss. The authors studied the function of local retinal areas in the posterior pole of patients with OMD using multifocal electroretinograms (ERGs). METHODS Multifocal ERGs were recorded using the Visual Evoked Resp...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2015

ISSN: 1552-5783

DOI: 10.1167/iovs.15-16742